Spain have the chance to secure top spot in World Cup Group H and send Uruguay home.
Luis de la Fuente’s side struggled to break down Cape Verde in their opener but bounced back with a convincing win over Saudi Arabia.
Uruguay are in a tricky situation. A draw could potentially be enough for them to go through to the round of 32 but they need to beat the European champions to make sure.
That looks a tall order given the reports of unrest within Marcelo Bielsa’s squad.
Where to watch Uruguay v Spain: TV and online streams
Uruguay versus Spain kicks off at 1am in the early hours of Saturday morning. You can watch it on ITV1 and stream via ITVX.
Stats for Uruguay v Spain
- Spain have won five and drawn five of 10 previous meetings with Uruguay
- Their last meeting came at the 2013 Confederations Cup with Spain winning 2-1
- Spain are unbeaten in their last 33 games
- Uruguay have not won any of their last six games, drawing five
