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    Home»Top Countries»United States»Moderna shares surge after it says its experimental mRNA cancer treatment passed a key test
    United States

    Moderna shares surge after it says its experimental mRNA cancer treatment passed a key test

    News DeskBy News DeskAugust 19, 2026No Comments6 Mins Read
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    Moderna shares surge after it says its experimental mRNA cancer treatment passed a key test
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    ‘
    );
    }

    function setButtonState(button, state) {
    const hint = button.parentElement && button.parentElement.querySelector(‘[data-author-follow-hint]’);
    const followLabel = button.dataset.followLabel || ‘Follow’;
    const followingLabel = button.dataset.followingLabel || ‘Following’;
    const registerLabel = button.dataset.registerLabel || ‘Register to follow’;
    const loadingLabel = button.dataset.loadingLabel || ‘Saving…’;
    const pendingAuthLabel = button.dataset.pendingAuthLabel || ‘Loading…’;
    button.classList.remove(‘is-following’, ‘is-loading’, ‘is-auth-required’);

    if (state === ‘loading’) {
    button.classList.add(‘is-loading’);
    button.disabled = true;
    button.textContent = loadingLabel;
    if (hint) {
    hint.textContent=”Updating your followed authors…”;
    }
    return;
    }

    if (state === ‘pending-auth’) {
    button.classList.add(‘is-loading’);
    button.disabled = true;
    button.textContent = pendingAuthLabel;
    if (hint) {
    hint.textContent=”Checking your sign-in status…”;
    }
    return;
    }

    button.disabled = false;

    if (state === ‘following’) {
    button.classList.add(‘is-following’);
    button.textContent = followingLabel;
    if (hint) {
    hint.textContent = followingLabel === ‘Unfollow’
    ? ‘Remove this writer from your followed list.’
    : ‘Click again to unfollow.’;
    }
    return;
    }

    if (state === ‘signin’) {
    button.classList.add(‘is-auth-required’);
    button.textContent = registerLabel;
    if (hint) {
    hint.textContent=”Register to follow writers and manage your list.”;
    }
    return;
    }

    button.textContent = followLabel;
    if (hint) {
    hint.textContent=”Click to follow.”;
    }
    }

    function renderWidgets(scope) {
    const root = scope || document;
    root.querySelectorAll(‘[data-author-follow-widget]’).forEach(function (widget) {
    const button = widget.querySelector(‘[data-author-follow-button]’);
    if (!button) {
    return;
    }

    const staffId = widget.dataset.staffId;
    const hasToken = !!getBearerToken();

    if (!isPianoIdentityReady() && !hasToken) {
    setButtonState(button, ‘pending-auth’);
    return;
    }

    if (!hasToken) {
    setButtonState(button, ‘signin’);
    return;
    }

    if (followedAuthorsMap.has(String(staffId))) {
    setButtonState(button, ‘following’);
    } else {
    setButtonState(button, ‘follow’);
    }
    });
    }

    function renderManageList(container) {
    if (!container) {
    return;
    }

    const hasToken = !!getBearerToken();

    if (!isPianoIdentityReady() && !hasToken) {
    container.innerHTML = (
    ‘

    Checking your account status…

    ‘
    );
    return;
    }

    if (!hasToken) {
    container.innerHTML = (
    ‘

    Sign in to load the authors you follow. ‘ +
    ‘Sign in

    ‘
    );
    return;
    }

    const followedAuthors = Array.from(followedAuthorsMap.values());
    if (!followedAuthors.length) {
    container.innerHTML = (
    ‘

    You are not following any authors yet. ‘ +
    ‘Use the follow buttons on stories or staff pages to build your list.

    ‘
    );
    return;
    }

    container.innerHTML = followedAuthors
    .map(function (author) {
    return (
    ‘

    ‘ +
    ” +
    ‘

    ‘ +
    ‘‘ +
    ‘Remove this writer from your followed list.‘ +
    ‘

    ‘ +
    ‘

    ‘
    );
    })
    .join(”);

    bindEvents(container);
    renderWidgets(container);
    }

    async function refresh(scope, options) {
    const forceFetch = !!(options && options.force);

    if (!hasFollowWidgets(scope)) {
    return;
    }

    // Wipe the cached map BEFORE the first render so a user-switch can’t
    // momentarily display the previous user’s “Following” state.
    discardCacheIfTokenChanged();

    renderWidgets(scope);

    const manageContainer = document.querySelector(‘[data-author-follow-manage-list]’);
    const managePreferencesContainer = document.querySelector(‘[data-author-follow-manage-preferences]’);
    const hasToken = !!getBearerToken();

    if (!isPianoIdentityReady() && !hasToken) {
    renderWidgets(scope);
    renderManagePreferences(managePreferencesContainer);
    renderManageList(manageContainer);
    return;
    }

    if (!hasToken) {
    renderManagePreferences(managePreferencesContainer);
    renderManageList(manageContainer);
    return;
    }

    try {
    await loadFollowedAuthors(forceFetch);
    renderWidgets(scope);
    renderManagePreferences(managePreferencesContainer);
    renderManageList(manageContainer);
    } catch (error) {
    console.warn(‘Unable to load followed authors.’, error);
    if (error && error.code === ‘AUTH_REQUIRED’) {
    renderWidgets(scope);
    renderManagePreferences(managePreferencesContainer);
    renderManageList(manageContainer);
    }
    }
    }

    function startLoginPoll() {
    if (loginPoll) {
    clearInterval(loginPoll);
    }

    let attempts = 0;
    loginPoll = setInterval(function () {
    attempts += 1;
    if (getBearerToken() || isLoggedIn() || attempts > 25) {
    clearInterval(loginPoll);
    loginPoll = null;
    refresh(document, { force: true });
    }
    }, 1000);
    }

    function stopPianoReadyPoll() {
    if (pianoReadyPoll) {
    clearInterval(pianoReadyPoll);
    pianoReadyPoll = null;
    }
    }

    function startPianoReadyPoll() {
    stopPianoReadyPoll();

    let attempts = 0;
    pianoReadyPoll = setInterval(function () {
    attempts += 1;
    if (isPianoIdentityReady() || getBearerToken() || attempts > 40) {
    stopPianoReadyPoll();
    // Non-forced: if bindPianoInitRefresh already fetched, the TTL
    // dedupes this call. If it lost the race, this call wins.
    refresh(document);
    }
    }, 500);
    }

    function bindPianoInitRefresh() {
    if (pianoInitBound) {
    return;
    }

    pianoInitBound = whenPianoReady(function () {
    // The Piano init callback is the canonical “identity is ready” signal;
    // cancel the fallback poll so it can’t issue a redundant second fetch.
    stopPianoReadyPoll();
    refresh(document, { force: true });
    });
    }

    async function handleWidgetClick(widget, button) {
    const staffId = widget.dataset.staffId;

    if (!getBearerToken()) {
    setButtonState(button, isPianoIdentityReady() ? ‘signin’ : ‘pending-auth’);
    if (typeof window.showPianoRegister === ‘function’) {
    window.showPianoRegister();
    startLoginPoll();
    }
    return;
    }

    // If the identity changed since the cache was last filled, drop the stale
    // map before the follow/unfollow decision below — otherwise the click
    // could issue the wrong action against the previous user’s state.
    discardCacheIfTokenChanged();

    setButtonState(button, ‘loading’);

    try {
    if (followedAuthorsMap.has(String(staffId))) {
    await apiRequest(apiBaseUrl + “https://www.washingtontimes.com/” + staffId, { method: ‘DELETE’ });
    followedAuthorsMap.delete(String(staffId));
    removePushlyFollowedAuthorId(staffId);
    } else {
    const author = await apiRequest(apiBaseUrl + “https://www.washingtontimes.com/” + staffId, {
    method: ‘PUT’,
    body: JSON.stringify({
    push_enabled: followDeliveryPreferences.push_enabled,
    email_fallback_enabled: followDeliveryPreferences.email_fallback_enabled,
    }),
    });
    followedAuthorsMap.set(String(staffId), author);
    appendPushlyFollowedAuthorId(staffId);
    }

    saveStoredFollowDeliveryPreferences(
    deriveFollowDeliveryPreferences(Array.from(followedAuthorsMap.values())),
    );
    syncPushlyFollowedAuthorsProfile();
    renderManagePreferences(document.querySelector(‘[data-author-follow-manage-preferences]’));
    renderWidgets(document);
    renderManageList(document.querySelector(‘[data-author-follow-manage-list]’));
    } catch (error) {
    console.warn(‘Unable to update followed author.’, error);
    if (error && error.code === ‘AUTH_REQUIRED’) {
    setButtonState(button, ‘signin’);
    }
    renderWidgets(document);
    }
    }

    function bindEvents(scope) {
    const root = scope || document;
    root.querySelectorAll(‘[data-author-follow-widget]’).forEach(function (widget) {
    if (widget.dataset.followWidgetBound === ‘true’) {
    return;
    }
    widget.dataset.followWidgetBound = ‘true’;

    const button = widget.querySelector(‘[data-author-follow-button]’);
    if (!button) {
    return;
    }

    button.addEventListener(‘click’, function () {
    handleWidgetClick(widget, button);
    });
    });

    root.querySelectorAll(‘[data-author-follow-manage-preferences]’).forEach(function (container) {
    if (container.dataset.followGlobalPreferencesBound === ‘true’) {
    return;
    }
    container.dataset.followGlobalPreferencesBound = ‘true’;

    async function handlePreferenceChange() {
    const pushInput = container.querySelector(‘[data-author-follow-global-pref=”push”]’);
    const emailInput = container.querySelector(‘[data-author-follow-global-pref=”email”]’);
    if (!pushInput || !emailInput) {
    return;
    }

    const previousPreferences = {
    push_enabled: followDeliveryPreferences.push_enabled,
    email_fallback_enabled: followDeliveryPreferences.email_fallback_enabled,
    };
    const payload = {
    push_enabled: !!pushInput.checked,
    email_fallback_enabled: !!emailInput.checked,
    };
    // Drop a stale map if the identity changed before iterating — we
    // don’t want to issue follow updates against the previous user’s
    // authors with the current user’s bearer token.
    discardCacheIfTokenChanged();
    const followedAuthors = Array.from(followedAuthorsMap.values());

    saveStoredFollowDeliveryPreferences(payload);
    managePreferencesPending = true;
    pushInput.disabled = true;
    emailInput.disabled = true;

    try {
    await Promise.all(
    followedAuthors.map(function (author) {
    return updateFollowPreferences(author.id, payload);
    }),
    );
    renderManagePreferences(container);
    renderWidgets(document);
    renderManageList(document.querySelector(‘[data-author-follow-manage-list]’));
    } catch (error) {
    console.warn(‘Unable to update author follow preferences.’, error);
    saveStoredFollowDeliveryPreferences(previousPreferences);
    pushInput.checked = previousPreferences.push_enabled;
    emailInput.checked = previousPreferences.email_fallback_enabled;
    } finally {
    managePreferencesPending = false;
    pushInput.disabled = false;
    emailInput.disabled = false;
    }
    }

    container.addEventListener(‘change’, function (event) {
    const target = event.target;
    if (!target || !target.matches(‘[data-author-follow-global-pref]’)) {
    return;
    }
    handlePreferenceChange();
    });
    });
    }

    function init(scope) {
    const root = scope || document;
    if (!hasFollowWidgets(root)) {
    return;
    }
    bindEvents(root);
    renderWidgets(root);
    bindPianoInitRefresh();
    startPianoReadyPoll();
    refresh(root);
    }

    window.WTAuthorFollow = {
    init: init,
    refresh: refresh,
    };

    document.addEventListener(‘DOMContentLoaded’, function () {
    init(document);
    });

    window.addEventListener(‘focus’, function () {
    if (hasFollowWidgets(document)) {
    refresh(document);
    }
    });
    document.addEventListener(‘visibilitychange’, function () {
    if (!document.hidden && hasFollowWidgets(document)) {
    refresh(document);
    }
    });
    } else {
    window.WTAuthorFollow.init(document);
    }
    })();


    FILE – A sign marks an entrance to a Moderna building in Cambridge, Mass., May 18, 2020. (AP Photo/Bill Sikes, File)prnto


    FILE – A sign marks an …

    more >


    By Associated Press –

    Wednesday, August 19, 2026


    Moderna shares more than doubled Wednesday after it announced initial results from a study of an experimental cancer treatment that would be the first of its kind if approved by regulators.

    Moderna and Merck are developing a treatment using an mRNA-based cancer vaccine called intismeran that is designed to be tailored to individual patients based on unique mutations within their tumors. In current studies, they are pairing it with Keytruda, a immunotherapy drug made by Merck.

    The study compared using intismeran and Keytruda together on melanoma patients against using Keytruda alone. The companies said patients who received the combination lived longer without cancer returning or metastasizing than patients who got Keytruda alone.

    The companies did not say how long patients survived without cancer returning or whether patients lived longer overall. They said they plan to present the study results at an upcoming international medical meeting.

    Moderna shares rose more than 120% to $140.12 a share. Merck shares rose about 11%.

    Copyright © 2026 The Washington Times, LLC.

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